EXTH-25. A MECHANICALLY-ENGINEERED SPRAY TO INCREASE BRAIN PENETRATION OF CHEMOTHERAPEUTIC NANOPARTICLES IN THE TREATMENT OF HIGH GRADE GLIOMAS

Design and implementation of innovative local drug delivery systems (DDS) may overcome current limitations in GBM treatment, such as the lack of therapeutic drug concentrations reaching residual GBM cells following surgery. Here we describe a novel DDS which utilises a bespoke mechanically engineere...

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Vydáno v:Neuro Oncol
Hlavní autoři: McCrorie, Phoebe, Taresco, Vincenzo, Ritchie, Alison, Clarke, Phillip, Scurr, David, Marlow, Maria, Rahman, Ruman
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846913/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.358
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