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A mechanically-engineered spray to increase brain penetration of chemotherapeutic nanoparticles in the treatment of high-grade gliomas

Design and implementation of innovative local drug delivery systems (DDS) may overcome current limitations in GBM treatment, such as the lack of therapeutic drug concentrations reaching residual GBM cells following surgery. Here we describe a novel DDS which utilises a bespoke mechanically engineere...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: McCrorie, Phoebe, Taresco, Vincenco, Xu, Zeyuan, Ritchie, Alison, Clarke, Phillip, Marlow, Maria, Rahman, Ruman
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789704/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz167.002
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