Screening identifies small molecules that enhance the maturation of human pluripotent stem cell-derived myotubes

Targeted differentiation of pluripotent stem (PS) cells into myotubes enables in vitro disease modeling of skeletal muscle diseases. Although various protocols achieve myogenic differentiation in vitro, resulting myotubes typically display an embryonic identity. This is a major hurdle for accurately...

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Bibliographische Detailangaben
Veröffentlicht in:eLife
Hauptverfasser: Selvaraj, Sridhar, Mondragon-Gonzalez, Ricardo, Xu, Bin, Magli, Alessandro, Kim, Hyunkee, Lainé, Jeanne, Kiley, James, Mckee, Holly, Rinaldi, Fabrizio, Aho, Joy, Tabti, Nacira, Shen, Wei, Perlingeiro, Rita CR
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6845233/
https://ncbi.nlm.nih.gov/pubmed/31710288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47970
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