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Modulation of PDCD1 exon 3 splicing
The PDCD1 gene encodes PD-1, an important immune checkpoint protein and key immunotherapy target to treat cancer. PDCD1 is alternatively spliced to generate an exon 3-skipped isoform PD-1Δ3 that has been suggested to play an antagonistic role to PD-1, but the mechanism underlying alternative splicin...
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| Veröffentlicht in: | RNA Biol |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6844568/ https://ncbi.nlm.nih.gov/pubmed/31441370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2019.1659080 |
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