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Modulation of PDCD1 exon 3 splicing

The PDCD1 gene encodes PD-1, an important immune checkpoint protein and key immunotherapy target to treat cancer. PDCD1 is alternatively spliced to generate an exon 3-skipped isoform PD-1Δ3 that has been suggested to play an antagonistic role to PD-1, but the mechanism underlying alternative splicin...

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Bibliografiske detaljer
Udgivet i:RNA Biol
Main Authors: Sun, Junjie, Bai, Jialin, Jiang, Tao, Gao, Yuan, Hua, Yimin
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844568/
https://ncbi.nlm.nih.gov/pubmed/31441370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2019.1659080
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