Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent Fluorescence Quenching

[Image: see text] DNA topoisomerases are essential enzymes for all living organisms and important targets for anticancer drugs and antibiotics. Although DNA topoisomerases have been studied extensively, steady-state kinetics has not been systematically investigated because of the lack of an appropri...

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Publicat a:ACS Omega
Autors principals: Wang, Yunke, Rakela, Samantha, Chambers, Jeremy W., Hua, Zi-Chun, Muller, Mark T., Nitiss, John L., Tse-Dinh, Yuk-Ching, Leng, Fenfei
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844113/
https://ncbi.nlm.nih.gov/pubmed/31720544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b02676
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