Both gain and loss of Nampt function promote pressure overload-induced heart failure

The heart requires high-energy production, but metabolic ability declines in the failing heart. Nicotinamide phosphoribosyl-transferase (Nampt) is a rate-limiting enzyme in the salvage pathway of nicotinamide adenine dinucleotide (NAD) synthesis. NAD is directly involved in various metabolic process...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Byun, Jaemin, Oka, Shin-ichi, Imai, Nobushige, Huang, Chun-Yang, Ralda, Guersom, Zhai, Peiyong, Ikeda, Yoshiyuki, Ikeda, Shohei, Sadoshima, Junichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6843022/
https://ncbi.nlm.nih.gov/pubmed/31347918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00222.2019
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