Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation

Genome-wide association studies (GWAS) and functional genomic analyses have implicated several ITGAM (CD11b) single-nucleotide polymorphisms (SNPs) in the development of SLE and other disorders. ITGAM encodes the α(M) chain of the β(2) integrin Mac-1, a receptor that plays important roles in myeloid...

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Udgivet i:Mamm Genome
Main Authors: Avery, Justin T., Jimenez, Rachel V., Blake, Joseph L., Wright, Tyler T., Leόn-Ruiz, Beatriz, Schoeb, Trenton R., Szalai, Alexander J., Bullard, Daniel C.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842653/
https://ncbi.nlm.nih.gov/pubmed/31673770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00335-019-09819-y
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