The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes

OBJECTIVES: The rs1143679 variant of ITGAM, encoding the R77H variant of CD11b (part of complement receptor 3; CR3), is among the strongest genetic susceptibility effects in human systemic lupus erythematosus (SLE). The authors aimed to demonstrate R77H function in ex-vivo human cells. METHODS: Mono...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Rhodes, Benjamin, Fürnrohr, Barbara G, Roberts, Amy L, Tzircotis, George, Schett, Georg, Spector, Tim D, Vyse, Timothy J
Format: Artigo
Sprog:Inglês
Udgivet: BMJ Group 2012
Fag:
Basic and Translational Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488763/
https://ncbi.nlm.nih.gov/pubmed/22586164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2012-201390
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker