The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes

OBJECTIVES: The rs1143679 variant of ITGAM, encoding the R77H variant of CD11b (part of complement receptor 3; CR3), is among the strongest genetic susceptibility effects in human systemic lupus erythematosus (SLE). The authors aimed to demonstrate R77H function in ex-vivo human cells. METHODS: Mono...

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Detalhes bibliográficos
Main Authors: Rhodes, Benjamin, Fürnrohr, Barbara G, Roberts, Amy L, Tzircotis, George, Schett, Georg, Spector, Tim D, Vyse, Timothy J
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2012
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3488763/
https://ncbi.nlm.nih.gov/pubmed/22586164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2012-201390
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