Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM

Integrin alpha M (ITGAM; CD11b) is a component of the macrophage-1 antigen complex, which mediates leukocyte adhesion, migration and phagocytosis as part of the immune system. We previously identified a missense polymorphism, rs1143679 (R77H), strongly associated with systemic lupus erythematosus (S...

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Detalhes bibliográficos
Main Authors: Maiti, Amit K., Kim-Howard, Xana, Motghare, Prasenjeet, Pradhan, Vandana, Chua, Kek Heng, Sun, Celi, Arango-Guerrero, María Teresa, Ghosh, Kanjaksha, Niewold, Timothy B., Harley, John B., Anaya, Juan-Manual, Looger, Loren L., Nath, Swapan K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Association Studies Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4082363/
https://ncbi.nlm.nih.gov/pubmed/24608226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu106
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