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Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples

Human cysteine cathepsins constitute an 11-membered family of proteases responsible for degradation of proteins in cellular endosomal–lysosomal compartments as such, they play important roles in antigen processing, cellular stress signaling, autophagy, and senescence. Moreover, for many years these...

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Vydáno v:Chem Sci
Hlavní autoři: Poreba, Marcin, Groborz, Katarzyna, Vizovisek, Matej, Maruggi, Marco, Turk, Dusan, Turk, Boris, Powis, Garth, Drag, Marcin, Salvesen, Guy S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6839509/
https://ncbi.nlm.nih.gov/pubmed/31803426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc00997c
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