TIP60/KAT5 is required for neuronal viability in hippocampal CA1

Aberrant histone acetylation contributes to age-dependent cognitive decline and neurodegenerative diseases. We analyze the function of lysine acetyltransferase TIP60/KAT5 in neurons of the hippocampus using an inducible mouse model. TIP60-deficiency in the adult forebrain leads within days to extens...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Urban, Inga, Kerimoglu, Cemil, Sakib, M. Sadman, Wang, Haifang, Benito, Eva, Thaller, Christina, Zhou, Xunlei, Yan, Jun, Fischer, André, Eichele, Gregor
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838100/
https://ncbi.nlm.nih.gov/pubmed/31700011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50927-1
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