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NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex

The DNA damage response (DDR) signal transduction pathway is responsible for sensing DNA damage and further relaying this signal into the cell. ATM is an apical DDR kinase that orchestrates the activation and the recruitment of downstream DDR factors to induce cell-cycle arrest and repair. We have p...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Adamowicz, Marek, Vermezovic, Jelena, d’Adda di Fagagna, Fabrizio
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003812/
https://ncbi.nlm.nih.gov/pubmed/27524627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.038
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