Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data

Tumors are made of evolving and heterogeneous populations of cells which arise from successive appearance and expansion of subclonal populations, following acquisition of mutations conferring them a selective advantage. Those subclonal populations can be sensitive or resistant to different treatment...

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Vydáno v:PLoS One
Hlavní autoři: Abécassis, Judith, Hamy, Anne-Sophie, Laurent, Cécile, Sadacca, Benjamin, Bonsang-Kitzis, Hélène, Reyal, Fabien, Vert, Jean-Philippe
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837753/
https://ncbi.nlm.nih.gov/pubmed/31697689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0224143
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