Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity

Multi-region sequencing is used to detect intratumor genetic heterogeneity (ITGH) in tumors. To assess whether genuine ITGH can be distinguished from sequencing artifacts, we performed whole-exome sequencing (WES) on three anatomically distinct regions of the same tumor with technical replicates to...

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Udgivet i:Cell Rep
Main Authors: Shi, Weiwei, Ng, Charlotte K.Y., Lim, Raymond S., Jiang, Tingting, Kumar, Sushant, Li, Xiaotong, Wali, Vikram B., Piscuoglio, Salvatore, Gerstein, Mark B., Chagpar, Anees B., Weigelt, Britta, Pusztai, Lajos, Reis-Filho, Jorge S., Hatzis, Christos
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261536/
https://ncbi.nlm.nih.gov/pubmed/30404001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.046
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