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Reliability of Whole-Exome Sequencing for Assessing Intratumor Genetic Heterogeneity
Multi-region sequencing is used to detect intratumor genetic heterogeneity (ITGH) in tumors. To assess whether genuine ITGH can be distinguished from sequencing artifacts, we performed whole-exome sequencing (WES) on three anatomically distinct regions of the same tumor with technical replicates to...
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| Udgivet i: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6261536/ https://ncbi.nlm.nih.gov/pubmed/30404001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.046 |
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