Statistical measures of transcriptional diversity capture genomic heterogeneity of cancer

BACKGROUND: Molecular heterogeneity of tumors suggests the presence of multiple different subclones that may limit response to targeted therapies and contribute to acquisition of drug resistance, but its quantification has remained challenging. RESULTS: We performed simulations to evaluate statistic...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Jiang, Tingting, Shi, Weiwei, Natowicz, René, Ononye, Sophia N, Wali, Vikram B, Kluger, Yuval, Pusztai, Lajos, Hatzis, Christos
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2014
Gaiak:
Methodology Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197225/
https://ncbi.nlm.nih.gov/pubmed/25294321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-876
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