Statistical measures of transcriptional diversity capture genomic heterogeneity of cancer

BACKGROUND: Molecular heterogeneity of tumors suggests the presence of multiple different subclones that may limit response to targeted therapies and contribute to acquisition of drug resistance, but its quantification has remained challenging. RESULTS: We performed simulations to evaluate statistic...

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Autori principali: Jiang, Tingting, Shi, Weiwei, Natowicz, René, Ononye, Sophia N, Wali, Vikram B, Kluger, Yuval, Pusztai, Lajos, Hatzis, Christos
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
Soggetti:
Methodology Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197225/
https://ncbi.nlm.nih.gov/pubmed/25294321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-876
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