Statistical measures of transcriptional diversity capture genomic heterogeneity of cancer

BACKGROUND: Molecular heterogeneity of tumors suggests the presence of multiple different subclones that may limit response to targeted therapies and contribute to acquisition of drug resistance, but its quantification has remained challenging. RESULTS: We performed simulations to evaluate statistic...

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Detaylı Bibliyografya
Asıl Yazarlar: Jiang, Tingting, Shi, Weiwei, Natowicz, René, Ononye, Sophia N, Wali, Vikram B, Kluger, Yuval, Pusztai, Lajos, Hatzis, Christos
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2014
Konular:
Methodology Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197225/
https://ncbi.nlm.nih.gov/pubmed/25294321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-876
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