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Statistical measures of transcriptional diversity capture genomic heterogeneity of cancer
BACKGROUND: Molecular heterogeneity of tumors suggests the presence of multiple different subclones that may limit response to targeted therapies and contribute to acquisition of drug resistance, but its quantification has remained challenging. RESULTS: We performed simulations to evaluate statistic...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4197225/ https://ncbi.nlm.nih.gov/pubmed/25294321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-876 |
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