Statistical measures of transcriptional diversity capture genomic heterogeneity of cancer

BACKGROUND: Molecular heterogeneity of tumors suggests the presence of multiple different subclones that may limit response to targeted therapies and contribute to acquisition of drug resistance, but its quantification has remained challenging. RESULTS: We performed simulations to evaluate statistic...

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Библиографические подробности
Главные авторы: Jiang, Tingting, Shi, Weiwei, Natowicz, René, Ononye, Sophia N, Wali, Vikram B, Kluger, Yuval, Pusztai, Lajos, Hatzis, Christos
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2014
Предметы:
Methodology Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197225/
https://ncbi.nlm.nih.gov/pubmed/25294321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-15-876
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