Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data

Tumors are made of evolving and heterogeneous populations of cells which arise from successive appearance and expansion of subclonal populations, following acquisition of mutations conferring them a selective advantage. Those subclonal populations can be sensitive or resistant to different treatment...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Abécassis, Judith, Hamy, Anne-Sophie, Laurent, Cécile, Sadacca, Benjamin, Bonsang-Kitzis, Hélène, Reyal, Fabien, Vert, Jean-Philippe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6837753/
https://ncbi.nlm.nih.gov/pubmed/31697689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0224143
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