Lessons from LIMK1 enzymology and their impact on inhibitor design

LIM domain kinase 1 (LIMK1) is a key regulator of actin dynamics. It is thereby a potential therapeutic target for the prevention of fragile X syndrome and amyotrophic lateral sclerosis. Herein, we use X-ray crystallography and activity assays to describe how LIMK1 accomplishes substrate specificity...

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Vydáno v:Biochem J
Hlavní autoři: Salah, Eidarus, Chatterjee, Deep, Beltrami, Alessandra, Tumber, Anthony, Preuss, Franziska, Canning, Peter, Chaikuad, Apirat, Knaus, Petra, Knapp, Stefan, Bullock, Alex N., Mathea, Sebastian
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6835155/
https://ncbi.nlm.nih.gov/pubmed/31652302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20190517
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