High-content analysis of constitutive androstane receptor (CAR) translocation identifies mosapride citrate as a CAR agonist that represses gluconeogenesis

The constitutive androstane receptor (CAR) plays an important role in hepatic drug metabolism and detoxification but has recently been projected as a potential drug target for metabolic disorders due to its repression of lipogenesis and gluconeogenesis. Thus, identification of physiologically-releva...

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Bibliographische Detailangaben
Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Mackowiak, Bryan, Li, Linhao, Lynch, Caitlin, Ziman, Andrew, Heyward, Scott, Xia, Menghang, Wang, Hongbing
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6833947/
https://ncbi.nlm.nih.gov/pubmed/31306645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2019.07.013
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