Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library

The constitutive androstane receptor (CAR; NR1I3) is a nuclear receptor involved in all phases of drug metabolism and disposition. However, recently it’s been implicated in energy metabolism, tumor progression, and cancer therapy as well. It is, therefore, important to identify compounds that induce...

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Bibliografiske detaljer
Udgivet i:Toxicol Sci
Main Authors: Lynch, Caitlin, Mackowiak, Bryan, Huang, Ruili, Li, Linhao, Heyward, Scott, Sakamuru, Srilatha, Wang, Hongbing, Xia, Menghang
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Tox21 SCREENING FOR CAR RECEPTOR ACTIVATION
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657574/
https://ncbi.nlm.nih.gov/pubmed/30247703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy242
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