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Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library

The constitutive androstane receptor (CAR; NR1I3) is a nuclear receptor involved in all phases of drug metabolism and disposition. However, recently it’s been implicated in energy metabolism, tumor progression, and cancer therapy as well. It is, therefore, important to identify compounds that induce...

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Bibliographic Details
Published in:Toxicol Sci
Main Authors: Lynch, Caitlin, Mackowiak, Bryan, Huang, Ruili, Li, Linhao, Heyward, Scott, Sakamuru, Srilatha, Wang, Hongbing, Xia, Menghang
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657574/
https://ncbi.nlm.nih.gov/pubmed/30247703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy242
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