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Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library
The constitutive androstane receptor (CAR; NR1I3) is a nuclear receptor involved in all phases of drug metabolism and disposition. However, recently it’s been implicated in energy metabolism, tumor progression, and cancer therapy as well. It is, therefore, important to identify compounds that induce...
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| Published in: | Toxicol Sci |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6657574/ https://ncbi.nlm.nih.gov/pubmed/30247703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy242 |
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