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Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library

The constitutive androstane receptor (CAR; NR1I3) is a nuclear receptor involved in all phases of drug metabolism and disposition. However, recently it’s been implicated in energy metabolism, tumor progression, and cancer therapy as well. It is, therefore, important to identify compounds that induce...

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書目詳細資料
發表在:Toxicol Sci
Main Authors: Lynch, Caitlin, Mackowiak, Bryan, Huang, Ruili, Li, Linhao, Heyward, Scott, Sakamuru, Srilatha, Wang, Hongbing, Xia, Menghang
格式: Artigo
語言:Inglês
出版: Oxford University Press 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6657574/
https://ncbi.nlm.nih.gov/pubmed/30247703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy242
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