Quantitative High-Throughput Identification of Drugs as Modulators of Human Constitutive Androstane Receptor

The constitutive androstane receptor (CAR, NR1I3) plays a key role in governing the transcription of numerous hepatic genes that involve xenobiotic metabolism/clearance, energy homeostasis, and cell proliferation. Thus, identification of novel human CAR (hCAR) modulators may not only enhance early p...

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Vydáno v:Sci Rep
Hlavní autoři: Lynch, Caitlin, Zhao, Jinghua, Huang, Ruili, Xiao, Jingwei, Li, Linhao, Heyward, Scott, Xia, Menghang, Wang, Hongbing
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4438668/
https://ncbi.nlm.nih.gov/pubmed/25993555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10405
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