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Quantitative High-throughput Luciferase Screening in Identifying CAR Modulators

The constitutive androstane receptor (CAR, NR1I3) is responsible for the transcription of multiple drug metabolizing enzymes and transporters. There are two possible methods of activation for CAR, direct ligand binding and a ligand-independent method, which makes this a unique nuclear receptor. Both...

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Detalhes bibliográficos
Publicado no:Methods Mol Biol
Main Authors: Lynch, Caitlin, Zhao, Jinghua, Wang, Hongbing, Xia, Menghang
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341601/
https://ncbi.nlm.nih.gov/pubmed/27518621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-6346-1_4
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