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Quantitative High-throughput Luciferase Screening in Identifying CAR Modulators
The constitutive androstane receptor (CAR, NR1I3) is responsible for the transcription of multiple drug metabolizing enzymes and transporters. There are two possible methods of activation for CAR, direct ligand binding and a ligand-independent method, which makes this a unique nuclear receptor. Both...
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| Publicat a: | Methods Mol Biol |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341601/ https://ncbi.nlm.nih.gov/pubmed/27518621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-6346-1_4 |
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