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Quantitative High-throughput Luciferase Screening in Identifying CAR Modulators
The constitutive androstane receptor (CAR, NR1I3) is responsible for the transcription of multiple drug metabolizing enzymes and transporters. There are two possible methods of activation for CAR, direct ligand binding and a ligand-independent method, which makes this a unique nuclear receptor. Both...
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| Publié dans: | Methods Mol Biol |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341601/ https://ncbi.nlm.nih.gov/pubmed/27518621 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-6346-1_4 |
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