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Human constitutive androstane receptor agonist DL5016: a novel sensitizer for cyclophosphamide-based chemotherapies

The DNA alkylating prodrug cyclophosphamide (CPA), alone or in combination with other agents, is one of the most commonly used anti-cancer agents. As a prodrug, CPA is activated by cytochrome P450 2B6 (CYP2B6), which is transcriptionally regulated by the human constitutive androstane receptor (hCAR)...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Liang, Dongdong, Li, Linhao, Lynch, Caitlin, Mackowiak, Bryan, Hedrich, William D., Ai, Yong, Yin, Yue, Heyward, Scott, Xia, Menghang, Wang, Hongbing, Xue, Fengtian
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6718324/
https://ncbi.nlm.nih.gov/pubmed/31247375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2019.06.031
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