New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising therapeutic target in cancer therapy. Combination chemotherapy using Tdp1 inhibitors as a component can potentially improve therapeutic response to many chemotherapeutic regimes. A new set of usnic acid derivatives with hydrazonothiazole pharmaco...

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Udgivet i:Molecules
Main Authors: Filimonov, Aleksander S., Chepanova, Arina A., Luzina, Olga A., Zakharenko, Alexandra L., Zakharova, Olga D., Ilina, Ekaterina S., Dyrkheeva, Nadezhda S., Kuprushkin, Maxim S., Kolotaev, Anton V., Khachatryan, Derenik S., Patel, Jinal, Leung, Ivanhoe K.H., Chand, Raina, Ayine-Tora, Daniel M., Reynisson, Johannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6832265/
https://ncbi.nlm.nih.gov/pubmed/31619021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24203711
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