New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising therapeutic target in cancer therapy. Combination chemotherapy using Tdp1 inhibitors as a component can potentially improve therapeutic response to many chemotherapeutic regimes. A new set of usnic acid derivatives with hydrazonothiazole pharmaco...

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Publicado no:Molecules
Main Authors: Filimonov, Aleksander S., Chepanova, Arina A., Luzina, Olga A., Zakharenko, Alexandra L., Zakharova, Olga D., Ilina, Ekaterina S., Dyrkheeva, Nadezhda S., Kuprushkin, Maxim S., Kolotaev, Anton V., Khachatryan, Derenik S., Patel, Jinal, Leung, Ivanhoe K.H., Chand, Raina, Ayine-Tora, Daniel M., Reynisson, Johannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6832265/
https://ncbi.nlm.nih.gov/pubmed/31619021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24203711
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