Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils

Neutrophils produce high levels of reactive oxygen species (ROS) by NADPH oxidase that are crucial for host defense but can lead to tissue injury when produced in excess. We previously described that proliferating cell nuclear antigen (PCNA), a nuclear scaffolding protein pivotal in DNA synthesis, c...

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Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Ohayon, Delphine, De Chiara, Alessia, Dang, Pham My-Chan, Thieblemont, Nathalie, Chatfield, Simon, Marzaioli, Viviana, Burgener, Sabrina Sofia, Mocek, Julie, Candalh, Céline, Pintard, Coralie, Tacnet-Delorme, Pascale, Renault, Gilles, Lagoutte, Isabelle, Favier, Maryline, Walker, Francine, Hurtado-Nedelec, Margarita, Desplancq, Dominique, Weiss, Etienne, Benarafa, Charaf, Housset, Dominique, Marie, Jean-Claude, Frachet, Philippe, El-Benna, Jamel, Witko-Sarsat, Véronique
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2019
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829599/
https://ncbi.nlm.nih.gov/pubmed/31492810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180371
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