Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils

Neutrophils produce high levels of reactive oxygen species (ROS) by NADPH oxidase that are crucial for host defense but can lead to tissue injury when produced in excess. We previously described that proliferating cell nuclear antigen (PCNA), a nuclear scaffolding protein pivotal in DNA synthesis, c...

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Vydáno v:J Exp Med
Hlavní autoři: Ohayon, Delphine, De Chiara, Alessia, Dang, Pham My-Chan, Thieblemont, Nathalie, Chatfield, Simon, Marzaioli, Viviana, Burgener, Sabrina Sofia, Mocek, Julie, Candalh, Céline, Pintard, Coralie, Tacnet-Delorme, Pascale, Renault, Gilles, Lagoutte, Isabelle, Favier, Maryline, Walker, Francine, Hurtado-Nedelec, Margarita, Desplancq, Dominique, Weiss, Etienne, Benarafa, Charaf, Housset, Dominique, Marie, Jean-Claude, Frachet, Philippe, El-Benna, Jamel, Witko-Sarsat, Véronique
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6829599/
https://ncbi.nlm.nih.gov/pubmed/31492810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180371
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