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Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils
Neutrophils produce high levels of reactive oxygen species (ROS) by NADPH oxidase that are crucial for host defense but can lead to tissue injury when produced in excess. We previously described that proliferating cell nuclear antigen (PCNA), a nuclear scaffolding protein pivotal in DNA synthesis, c...
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| 出版年: | J Exp Med |
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Rockefeller University Press
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6829599/ https://ncbi.nlm.nih.gov/pubmed/31492810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180371 |
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