The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation

The PIWI-interacting RNA (piRNA) pathway protects genome integrity in part through establishing repressive heterochromatin at transposon loci. Silencing requires piRNA-guided targeting of nuclear PIWI proteins to nascent transposon transcripts, yet the subsequent molecular events are not understood....

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Bibliografiska uppgifter
I publikationen:Nat Struct Mol Biol
Huvudupphovsmän: Batki, Julia, Schnabl, Jakob, Wang, Juncheng, Handler, Dominik, Andreev, Veselin I., Stieger, Christian E., Novatchkova, Maria, Lampersberger, Lisa, Kauneckaite, Kotryna, Xie, Wei, Mechtler, Karl, Patel, Dinshaw J., Brennecke, Julius
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6828549/
https://ncbi.nlm.nih.gov/pubmed/31384064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-019-0270-6
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