A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth

Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1) has been designed and developed. In a recent...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Lospinoso Severini, Ludovica, Quaglio, Deborah, Basili, Irene, Ghirga, Francesca, Bufalieri, Francesca, Caimano, Miriam, Balducci, Silvia, Moretti, Marta, Romeo, Isabella, Loricchio, Elena, Maroder, Marella, Botta, Bruno, Mori, Mattia, Infante, Paola, Di Marcotullio, Lucia
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826940/
https://ncbi.nlm.nih.gov/pubmed/31601026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11101518
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