Medroxyprogesterone acetate alters the vaginal microbiota and microenvironment in women and increases susceptibility to HIV-1 in humanized mice

The hormonal contraceptive medroxyprogesterone acetate (MPA) is associated with increased risk of human immunodeficiency virus (HIV), via incompletely understood mechanisms. Increased diversity in the vaginal microbiota modulates genital inflammation and is associated with increased HIV-1 acquisitio...

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Gepubliceerd in:Dis Model Mech
Hoofdauteurs: Wessels, Jocelyn M., Lajoie, Julie, Cooper, Maeve I. J. Hay, Omollo, Kenneth, Felker, Allison M., Vitali, Danielle, Dupont, Haley A., Nguyen, Philip V., Mueller, Kristen, Vahedi, Fatemeh, Kimani, Joshua, Oyugi, Julius, Cheruiyot, Juliana, Mungai, John N., Deshiere, Alexandre, Tremblay, Michel J., Mazzulli, Tony, Stearns, Jennifer C., Ashkar, Ali A., Fowke, Keith R., Surette, Michael G., Kaushic, Charu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Company of Biologists Ltd 2019
Onderwerpen:
Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6826019/
https://ncbi.nlm.nih.gov/pubmed/31537512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.039669
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