Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3-b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity

There are currently no approved drugs for the treatment of emerging viral infections, such as dengue and Ebola. Adaptor associated kinase 1 (AAK1) is a cellular serine/threonine protein kinase that functions as a key regulator of the clathrin-associated host adaptor proteins and regulates the intrac...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Med Chem
Main Authors: Verdonck, Sven, Pu, Szu-Yuan, Sorrell, Fiona J., Elkins, Jon M., Froeyen, Mathy, Gao, Ling-Jie, Prugar, Laura I., Dorosky, Danielle E., Brannan, Jennifer M., Barouch-Bentov, Rina, Knapp, Stefan, Dye, John M., Herdewijn, Piet, Einav, Shirit, Jonghe, Steven De
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825517/
https://ncbi.nlm.nih.gov/pubmed/31136173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00136
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki