Optimization of isothiazolo[4,3-b]pyridine-based inhibitors of cyclin G associated kinase (GAK) with broad-spectrum antiviral activity

There is an urgent need for strategies to combat dengue and other emerging viral infections. We reported that cyclin G-associated kinase (GAK), a cellular regulator of the clathrin-associated host adaptor proteins AP-1 and AP-2, regulates intracellular trafficking of multiple unrelated RNA viruses d...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Pu, Szu-Yuan, Wouters, Randy, Schor, Stanford, Rozenski, Jef, Bentov, Rina Barouch, Prugar, Laura I., O’Brien, Cecilia M., Brannan, Jennifer M., Dye, John M., Herdewijn, Piet, De Jonghe, Steven, Einav, Shirit
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6335200/
https://ncbi.nlm.nih.gov/pubmed/29953812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00613
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