Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3-b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity

There are currently no approved drugs for the treatment of emerging viral infections, such as dengue and Ebola. Adaptor associated kinase 1 (AAK1) is a cellular serine/threonine protein kinase that functions as a key regulator of the clathrin-associated host adaptor proteins and regulates the intrac...

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Publicado no:J Med Chem
Main Authors: Verdonck, Sven, Pu, Szu-Yuan, Sorrell, Fiona J., Elkins, Jon M., Froeyen, Mathy, Gao, Ling-Jie, Prugar, Laura I., Dorosky, Danielle E., Brannan, Jennifer M., Barouch-Bentov, Rina, Knapp, Stefan, Dye, John M., Herdewijn, Piet, Einav, Shirit, Jonghe, Steven De
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825517/
https://ncbi.nlm.nih.gov/pubmed/31136173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00136
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