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Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3-b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity
There are currently no approved drugs for the treatment of emerging viral infections, such as dengue and Ebola. Adaptor associated kinase 1 (AAK1) is a cellular serine/threonine protein kinase that functions as a key regulator of the clathrin-associated host adaptor proteins and regulates the intrac...
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| 出版年: | J Med Chem |
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| 主要な著者: | , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6825517/ https://ncbi.nlm.nih.gov/pubmed/31136173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00136 |
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