Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

Global health is threatened by emerging viral infections, which largely lack effective vaccines or therapies. Targeting host pathways that are exploited by multiple viruses could offer broad-spectrum solutions. We previously reported that AAK1 and GAK, kinase regulators of the host adaptor proteins...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Bekerman, Elena, Neveu, Gregory, Shulla, Ana, Brannan, Jennifer, Pu, Szu-Yuan, Wang, Stanley, Xiao, Fei, Barouch-Bentov, Rina, Bakken, Russell R., Mateo, Roberto, Govero, Jennifer, Nagamine, Claude M., Diamond, Michael S., De Jonghe, Steven, Herdewijn, Piet, Dye, John M., Randall, Glenn, Einav, Shirit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373883/
https://ncbi.nlm.nih.gov/pubmed/28240606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89857
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