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Selective inhibitors of Cyclin-G associated kinase (GAK) as anti-HCV agents

Cyclin-G associated kinase (GAK) emerged as a promising drug target for the treatment of viral infections. However, no potent and selective GAK inhibitors have been reported in the literature to date. This paper describes the discovery of isothiazolo[5,4-b]pyridines as selective GAK inhibitors, with...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Med Chem
Main Authors: Kovackova, Sona, Chang, Lei, Bekerman, Elena, Neveu, Gregory, Barouch-Bentov, Rina, Chaikuad, Apirat, Heroven, Christina, Šála, Michal, De Jonghe, Steven, Knapp, Stefan, Einav, Shirit, Herdewijn, Piet
פורמט: Artigo
שפה:Inglês
יצא לאור: 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431592/
https://ncbi.nlm.nih.gov/pubmed/25822739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501759m
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