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Selective inhibitors of Cyclin-G associated kinase (GAK) as anti-HCV agents

Cyclin-G associated kinase (GAK) emerged as a promising drug target for the treatment of viral infections. However, no potent and selective GAK inhibitors have been reported in the literature to date. This paper describes the discovery of isothiazolo[5,4-b]pyridines as selective GAK inhibitors, with...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Kovackova, Sona, Chang, Lei, Bekerman, Elena, Neveu, Gregory, Barouch-Bentov, Rina, Chaikuad, Apirat, Heroven, Christina, Šála, Michal, De Jonghe, Steven, Knapp, Stefan, Einav, Shirit, Herdewijn, Piet
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431592/
https://ncbi.nlm.nih.gov/pubmed/25822739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501759m
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