Isothiazolo[4,3-b]pyridines as inhibitors of cyclin G associated kinase : synthesis, structure-activity relationship studies and antiviral activity

Isothiazolo[4,3-b]pyridines are known to be endowed with potent affinity for cyclin G associated kinase (GAK). In this paper, we expanded the structure-activity relationship study by broadening the structural variety at position 3 of the isothiazolo[4,3-b]pyridine scaffold. The most potent GAK ligan...

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Bibliografiske detaljer
Udgivet i:Medchemcomm
Main Authors: Li, Jiahong, Kovackova, Sona, Pu, Szuyuan, Rozenski, Jef, De Jonghe, Steven, Einav, Shirit, Herdewijn, Piet
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763718/
https://ncbi.nlm.nih.gov/pubmed/26925208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5md00229j
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