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Proteostasis collapse is a driver of cell aging and death

What molecular processes drive cell aging and death? Here, we model how proteostasis—i.e., the folding, chaperoning, and maintenance of protein function—collapses with age from slowed translation and cumulative oxidative damage. Irreparably damaged proteins accumulate with age, increasingly distract...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Santra, Mantu, Dill, Ken A., de Graff, Adam M. R.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2019
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825304/
https://ncbi.nlm.nih.gov/pubmed/31619571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906592116
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