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Proteostasis collapse is a driver of cell aging and death

What molecular processes drive cell aging and death? Here, we model how proteostasis—i.e., the folding, chaperoning, and maintenance of protein function—collapses with age from slowed translation and cumulative oxidative damage. Irreparably damaged proteins accumulate with age, increasingly distract...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Santra, Mantu, Dill, Ken A., de Graff, Adam M. R.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825304/
https://ncbi.nlm.nih.gov/pubmed/31619571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906592116
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