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Aging as an Event of Proteostasis Collapse

Aging cells accumulate damaged and misfolded proteins through a functional decline in their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and the development of protein misfolding diseases such as Alzheimer’s and Huntington’s. Metabolic signaling pathways that r...

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Hlavní autoři: Taylor, Rebecca C., Dillin, Andrew
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101847/
https://ncbi.nlm.nih.gov/pubmed/21441594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a004440
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