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Aging as an Event of Proteostasis Collapse
Aging cells accumulate damaged and misfolded proteins through a functional decline in their protein homeostasis (proteostasis) machinery, leading to reduced cellular viability and the development of protein misfolding diseases such as Alzheimer’s and Huntington’s. Metabolic signaling pathways that r...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3101847/ https://ncbi.nlm.nih.gov/pubmed/21441594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a004440 |
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