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Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1
Loss of proteostasis and cellular senescence are key hallmarks of aging, but direct cause-effect relationships are not well understood. We show that most yeast cells arrest in G1 before death with low nuclear levels of Cln3, a key G1 cyclin extremely sensitive to chaperone status. Chaperone availabi...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6744273/ https://ncbi.nlm.nih.gov/pubmed/31518229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48240 |
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