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Molecular chaperones and neuronal proteostasis
Protein homeostasis (proteostasis) is essential for maintaining the functionality of the proteome. The disruption of proteostasis, due to genetic mutations or an age-related decline, leads to aberrantly folded proteins that typically lose their function. The accumulation of misfolded and aggregated...
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| Veröffentlicht in: | Semin Cell Dev Biol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4471145/ https://ncbi.nlm.nih.gov/pubmed/25770416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2015.03.003 |
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