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Molecular chaperones and neuronal proteostasis

Protein homeostasis (proteostasis) is essential for maintaining the functionality of the proteome. The disruption of proteostasis, due to genetic mutations or an age-related decline, leads to aberrantly folded proteins that typically lose their function. The accumulation of misfolded and aggregated...

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Detalhes bibliográficos
Publicado no:Semin Cell Dev Biol
Main Authors: Smith, Heather L., Li, Wenwen, Cheetham, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4471145/
https://ncbi.nlm.nih.gov/pubmed/25770416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2015.03.003
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