Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer

BACKGROUND: The fibroblast growth factor receptor (FGFR) signaling pathway is activated in multiple tumor types through gene amplifications, single base substitutions, or gene fusions. Multiple small molecule kinase inhibitors targeting FGFR are currently being evaluated in clinical trials for patie...

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Detalhes bibliográficos
Publicado no:Prostate Cancer Prostatic Dis
Main Authors: Krook, Melanie A., Barker, Hannah, Chen, Hui-Zi, Reeser, Julie W., Wing, Michele R., Martin, Dorrelyn, Smith, Amy M., Dao, Thuy, Bonneville, Russell, Samorodnitsky, Eric, Miya, Jharna, Freud, Aharon G., Monk, J. Paul, Clinton, Steven K., Roychowdhury, Sameek
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824932/
https://ncbi.nlm.nih.gov/pubmed/31043681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41391-019-0145-2
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