Characterization of a KLK2-FGFR2 fusion gene in two cases of metastatic prostate cancer

BACKGROUND: The fibroblast growth factor receptor (FGFR) signaling pathway is activated in multiple tumor types through gene amplifications, single base substitutions, or gene fusions. Multiple small molecule kinase inhibitors targeting FGFR are currently being evaluated in clinical trials for patie...

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Publicat a:Prostate Cancer Prostatic Dis
Autors principals: Krook, Melanie A., Barker, Hannah, Chen, Hui-Zi, Reeser, Julie W., Wing, Michele R., Martin, Dorrelyn, Smith, Amy M., Dao, Thuy, Bonneville, Russell, Samorodnitsky, Eric, Miya, Jharna, Freud, Aharon G., Monk, J. Paul, Clinton, Steven K., Roychowdhury, Sameek
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824932/
https://ncbi.nlm.nih.gov/pubmed/31043681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41391-019-0145-2
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