Efficacy of FGFR inhibitors and combination therapies for acquired resistance in FGFR2-fusion cholangiocarcinoma

The fibroblast growth factor receptor (FGFR) signaling pathway is aberrantly activated in approximately 15–20% of intrahepatic cholangiocarcinoma patients. Currently, several FGFR kinase inhibitors are being assessed in clinical trials for patients with FGFR-altered cholangiocarcinoma. Despite evide...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Krook, Melanie A., Lenyo, Alexandria, Wilberding, Max, Barker, Hannah, Dantuono, Mikayla, Bailey, Kelly M., Chen, Hui-Zi, Reeser, Julie W., Wing, Michele R., Miya, Jharna, Samorodnitsky, Eric, Smith, Amy M., Dao, Thuy, Martin, Dorrelyn M., Ciombor, Kristen K., Hays, John, Freud, Aharon G., Roychowdhury, Sameek
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7359896/
https://ncbi.nlm.nih.gov/pubmed/31911531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0631
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