A negative feedback regulatory loop between miR-138 and TP53 is mediated by USP10

TP53 is a critical tumor suppressor. In approximately 50% of human cancers the TP53 gene is either lost or mutated. The expression level of TP53 in the cells is tightly controlled by a fine-tune machinery, mainly through the Mdm2-mediated ubiquitination pathway. On the other side, the ubiquitinated...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Luo, Zhenghua, Zhang, Manchao, Cui, Ri, Tili, Esmerina, Kim, Taewan, Lee, Tae Jin, Peng, Yong, Croce, Carlo
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2019
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Priority Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824876/
https://ncbi.nlm.nih.gov/pubmed/31695837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27275
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