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TP53/miR-129/MDM2/4/TP53 feedback loop modulates cell proliferation and apoptosis in retinoblastoma

Retinoblastoma (RB) is commonly-seen cancer in children. The p53 pathway dysfunction, which can lead to elevated MDM2 or MDM4 (p53 antagonists) protein expression, is frequently observed in almost all human cancers, including RB. The present study attempted to investigate the underlying mechanism fr...

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Podrobná bibliografie
Vydáno v:Cell Cycle
Hlavní autoři: Yao, Xiaolei, Shen, Hui, Peng, Qinghua, Yu, Jingsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018471/
https://ncbi.nlm.nih.gov/pubmed/33678118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2021.1892321
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