TP53/miR-129/MDM2/4/TP53 feedback loop modulates cell proliferation and apoptosis in retinoblastoma

Retinoblastoma (RB) is commonly-seen cancer in children. The p53 pathway dysfunction, which can lead to elevated MDM2 or MDM4 (p53 antagonists) protein expression, is frequently observed in almost all human cancers, including RB. The present study attempted to investigate the underlying mechanism fr...

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Bibliographic Details
Published in:Cell Cycle
Main Authors: Yao, Xiaolei, Shen, Hui, Peng, Qinghua, Yu, Jingsheng
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2021
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8018471/
https://ncbi.nlm.nih.gov/pubmed/33678118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2021.1892321
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